When FBI Special Agent Joe Merriwether (Jeffrey Dean Morgan) is unable to solve a series of homicides, he decides to enlist the help of his former colleague Dr. John Clancy (Anthony Hopkins), a retired physician with psychic powers. When Clancy's exceptional intuitive powers put him on the trail of a suspect, Charles Ambrose (Colin Farrell), the doctor soon realizes his abilities are no match against the extraordinary powers of this vicious murderer on a mission.