A follow up to 2008's Quarantine, this entry picks up later that night at LAX, as passengers board a flight to Nashville. When a passenger becomes violently ill with a rabies-like virus, the plane makes an emergency landing at a metropolitan airport. Jenny, a heroic yet inexperienced flight attendant, takes charge. Relieved when a swarm of heavily equipped emergency vehicles and police arrive, Jenny and the passengers soon discover that they have been quarantined and are now trapped. Desperate to escape, Jenny enlists the help of one of the surviving passengers, Henry, to devise a plan to survive.