Space Chimps is an intergalactic comedy that highlights the antics of astronaut chimps on a mission in space, where they demonstrate as much of "the wrong stuff" as "the right stuff." Ham III, the slacker grandson of the first chimp blasted into space, is lured back into the space program and teams with two highly-trained chimps for a dangerous mission through a black hole to an inhabited planet. When they are stranded there, the chimps must help the inhabitants rid themselves of a tyrannical leader and figure out how to get back to Earth.