Starlet explores the unlikely cross-generational friendship between 21 year-old Jane (Dree Hemingway), and the elderly Sadie (Besedka Johnson), two women whose worlds collide in California's San Fernando Valley. Jane, an aspiring actress, spends her time getting high with her dysfunctional roommates, Melissa and Mikey (Stella Maeve and James Ransone), while caring for her Chihuahua, Starlet. Sadie, a widow, passes her days alone, tending to her flower garden. After a confrontation between the women at Sadie's yard sale, Jane uncovers a hidden stash of money inside a relic from Sadie's past. Jane attempts to befriend the caustic older woman in an effort to solve her dilemma and secrets emerge as their relationship grows.